Do not install the Windows Management Framework 3.0 (KB2506143) on SharePoint 2010 Servers19 Dec 2012 | SharePoint 2010
The Windows Management Framework 3.0 (KB2506143) includes PowerShell 3.0. Because SharePoint 2010 is based off of the .NET 3.5 Framework, it is incompatible with PowerShell 3.0, which is based off of the .NET 4.0 Framework. Installing this Optional update from Microsoft Update or the Microsoft Download Center will cause the SharePoint Management Shell to throw an error:
Add-PsSnapin : Incorrect Windows PowerShell version 3.0. Windows PowerShell ver sion 2.0 is supported in the current console. At C:\program files\common Files\microsoft shared\Web server extensions\14\conf ig\powershell\registration\sharepoint.ps1:3 char:13 + Add-PsSnapin <<<< Microsoft.SharePoint.PowerShell + CategoryInfo : InvalidArgument: (Microsoft.SharePoint.PowerShel l:String) [Add-PSSnapin], PSArgumentException + FullyQualifiedErrorId : AddPSSnapInRead,Microsoft.PowerShell.Commands.Ad dPSSnapinCommand
Uninstalling and rebooting the SharePoint Server will resolve this issue.
WMF 3.0 is also incompatible with Exchange 2007 and 2010, as well as some System Center products.
EDIT: The PowerShell team has put together a list of products with known compatibility issues as well as temporarily removed the WMF 3.0 from Windows Update:
EDIT2: And now a knowledge base article on this: